For 20 years, Dan Maurer had been living with a rare condition called scrotal lymphedema that causes the scrotum to grow to an enormous size. The condition had gone misdiagnosed and doctors had told him that he simply needed to lose weight. When he did lose weight and the mass continued to grow, he knew it was something else. It wasn't until he saw a piece on TLC featuring another man with the same condition that he realized what was going on. He immediately sought out treatment. Recently the mass was successfully removed.
You can read more about his story here.
And a video clip:
If you're curious about the surgical procedure to remove the mass, check out this video (NSFW, and features surgery):